The players' mission is to collect DNA from a dinosaur of your choice such as T. rex, Spinosaurus, Pteranodon, Brachiosaurus, Compy, Velociraptor, or Stegosaurus.

In the game the tokens are Ford Explorers from Jurassic Park, designed for up to 2 players. Danger Zone also recycles several cutscenes and menu designs from its predecessor. The Dino Defender Chief, a character who serves as both an authority figure and narrator, returns from the previous game to guide him through menus. The player is again cast as a Dino Defender. It was developed concurrently with the previously released Jurassic Park III: Dino Defender.

CD-ROM Jurassic Park III: Danger Zone! is a video board game based on Jurassic Park III for the PC.